Table of Contents

1. Introduction
2. Composition and Overview
3. Mechanism of Action
4. Uses of Ibuprofen and Paracetamol Suspension
5. Dosage and Administration
6. Common Side Effects
7. Serious Side Effects
8. Contraindications
9. Precautions and Warnings
10. Brand Names in India with MRP
11. Drug Interactions
12. Frequently Asked Questions (FAQs)
13. Conclusion

1. Introduction

Ibuprofen and Paracetamol Suspension is a widely prescribed combination medicine primarily used for the treatment of fever and pain in children. The dual-action formula provides effective relief by combining the anti-inflammatory properties of ibuprofen with the antipyretic and analgesic effects of paracetamol. This medication is a go-to solution for pediatricians when managing fevers, headaches, teething discomfort, sore throats, and mild body aches in children.

2. Composition and Overview

• Ibuprofen: A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever.
• Paracetamol (Acetaminophen): An analgesic and antipyretic that provides pain relief and reduces fever.

Ibuprofen and paracetamol suspension is usually available in a flavored liquid form, making it easier for children to consume. It is often used under medical supervision to ensure the correct dosage based on the child’s weight and age.

3. Mechanism of Action

Ibuprofen

Ibuprofen works by inhibiting the enzyme cyclooxygenase (COX-1 and COX-2), which plays a crucial role in the synthesis of prostaglandins. Prostaglandins are lipid compounds that mediate inflammation, pain, and fever. By blocking their production, ibuprofen effectively reduces inflammation, alleviates pain, and lowers body temperature.

Paracetamol (Acetaminophen)

Paracetamol’s exact mechanism isn’t completely understood, but it is believed to inhibit a form of cyclooxygenase (COX-3) in the brain, thereby reducing the synthesis of prostaglandins in the central nervous system. This helps in controlling fever and providing analgesic effects without the anti-inflammatory action seen with NSAIDs.

Ibuprofen and Paracetamol suspension works synergistically: while ibuprofen tackles inflammation and pain at the peripheral level, paracetamol acts centrally to enhance fever reduction and pain relief.

4. Uses of Ibuprofen and Paracetamol Suspension

This combination suspension is indicated for the treatment of:

• Fever due to infections (viral or bacterial)
• Headache
• Earache
• Toothache and teething pain in infants
• Post-vaccination fever
• Muscle pain and minor sprains
• Cold and flu symptoms
• Sore throat
• Mild to moderate pain due to injuries

5. Dosage and Administration

Dosage Guidelines

Dosage is generally based on the child’s weight and age. Always consult a pediatrician before administering the medication.

Age Group	Weight (Approx)	Recommended Dose	Frequency
6 months – 1 year	7-10 kg	2.5 mL	Every 6-8 hours
1 – 3 years	10-14 kg	5 mL	Every 6-8 hours
4 – 6 years	15-20 kg	7.5 mL	Every 6-8 hours
7 – 9 years	21-30 kg	10 mL	Every 6-8 hours

Note: Do not exceed four doses in 24 hours unless directed by a doctor.

6. Common Side Effects

Most children tolerate the suspension well. However, some may experience:

• Nausea
• Vomiting
• Mild abdominal discomfort
• Drowsiness
• Dizziness
• Loss of appetite
• Temporary changes in taste

These side effects are usually mild and transient.

7. Serious Side Effects

Though rare, serious adverse effects may occur:

• Allergic reactions (rash, itching, swelling)
• Breathing difficulty
• Severe stomach pain
• Jaundice (yellowing of the skin/eyes)
• Kidney or liver dysfunction

If any of these symptoms occur, discontinue use immediately and consult a physician.

8. Contraindications

This combination should not be used in:

• Children under 6 months of age
• Known allergy to ibuprofen, paracetamol, or other NSAIDs
• Children with peptic ulcers or gastrointestinal bleeding
• Severe liver or kidney impairment
• Children with bleeding disorders

9. Precautions and Warnings

• Always shake the bottle well before use.
• Use the measuring cup or dropper provided with the bottle.
• Do not use with other paracetamol-containing products to avoid overdose.
• Ensure adequate fluid intake to protect kidney function.
• Use with caution in asthmatic children, as NSAIDs can trigger bronchospasm.
• Long-term use should be avoided without medical advice.
• Monitor for signs of overdose, such as nausea, vomiting, and abdominal pain.

10. Brand Names in India with MRP

Here are some popular brands of Ibuprofen and Paracetamol Suspension available in India:

Brand Name	Manufacturer	MRP (Approx)	Pack Size
Combiflam Suspension	Sanofi India	₹35	60 ml
Ibugesic Plus Suspension	Cipla Ltd	₹40	60 ml
Brufen Plus Suspension	Abbott	₹38	60 ml
Flexon Suspension	Aristo Pharmaceuticals	₹34	60 ml
Ibunorm-P Suspension	Alkem Laboratories	₹36	60 ml
Pyrigesic Plus Suspension	East India Pharma	₹30	60 ml
Fevorid Plus Suspension	Medley Pharma	₹32	60 ml
Calpol Ibuprofen Plus Suspension	GSK	₹37	60 ml

Prices may vary slightly based on region, retailer, and applicable taxes.

11. Drug Interactions

The combination may interact with the following:

• Other NSAIDs (e.g., aspirin, naproxen)
• Blood thinners like warfarin
• Corticosteroids
• Antihypertensive drugs
• Methotrexate
• Anticonvulsants like phenytoin
• Alcohol – increases the risk of liver toxicity

Avoid concurrent use with multiple medicines containing paracetamol.

12. Frequently Asked Questions (FAQs)

Q1. Can I give ibuprofen and paracetamol suspension without a doctor’s advice?

It is best to consult a pediatrician before giving any medicine to a child. Dosage errors can be harmful.

Q2. Can I give this medicine with food or milk?

Yes, giving it with milk or food may help reduce stomach discomfort caused by ibuprofen.

Q3. What should I do if I miss a dose?

Give the missed dose as soon as you remember. If it’s near the time of the next dose, skip the missed one.

Q4. Can I use it for teething pain?

Yes, but under medical supervision. It’s effective for pain and inflammation due to teething.

Q5. What if my child vomits after taking the medicine?

If vomiting occurs within 30 minutes of administration, you may repeat the dose. If it’s later, wait for the next scheduled dose.

Q6. Can it be used for viral fever?

Yes, it provides symptomatic relief for fever and pain associated with viral infections.

Q7. How long can I use this suspension?

Do not use it for more than 3 consecutive days without medical advice.

Q8. Is it safe for infants below 6 months?

No, this combination is not recommended for infants under 6 months of age.

Q9. Can I give both paracetamol and ibuprofen separately?

Yes, but it should be done only under medical supervision to avoid dosing errors.

Q10. Is there a risk of liver damage?

Excessive use of paracetamol can cause liver damage. Always follow recommended dosage.

13. Conclusion

Ibuprofen and Paracetamol Suspension is a highly effective pediatric formulation for treating fever and mild-to-moderate pain. Its dual-action mechanism makes it a preferred choice among healthcare professionals. However, like any medication, it must be used cautiously, especially in children. Always adhere to recommended dosages and consult a pediatrician for prolonged symptoms.

For parents, understanding the benefits, proper usage, side effects, and precautions of this medicine ensures the safety and well-being of their children.

Disclaimer: This article is for informational purposes only and should not be used as a substitute for medical advice. Always consult a qualified healthcare provider for personalized guidance