Rabeprazole DSR Capsules Overview

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Table of Contents

  1. Introduction
  2. What are Rabeprazole DSR Capsules?
  3. Composition and Dosage
  4. Mechanism of Action
  5. Indications and Uses
  6. Dosage and Administration
  7. Storage Conditions
  8. Popular Rabeprazole DSR Brands in India with MRP
  9. Side Effects
  10. Precautions and Warnings
  11. Drug Interactions
  12. Frequently Asked Questions (FAQs)
  13. Conclusion

  1. Introduction

Digestive health issues like acidity, heartburn, and gastroesophageal reflux disease (GERD) are increasingly common due to modern lifestyles. Rabeprazole DSR capsules are widely used in India for the effective treatment of such disorders. This article provides a detailed overview of Rabeprazole DSR, including how it works, its uses, common side effects, brand availability, and frequently asked questions.

  1. What are Rabeprazole DSR Capsules?

Rabeprazole DSR is a combination drug that typically contains:

  • Rabeprazole Sodium (20 mg) – A proton pump inhibitor (PPI)
  • Domperidone (30 mg) – A dopamine antagonist with prokinetic properties

This dual formulation is designed for sustained release (SR) and delayed-release (DR) action, making it highly effective in treating gastric acidity and associated symptoms.

  1. Composition and Dosage

Each Rabeprazole DSR capsule generally contains:

  • Rabeprazole Sodium 20 mg (Enteric-coated)
  • Domperidone 30 mg (Sustained Release)

Common Dosage:

  • Usually, one capsule per day is prescribed, taken 30 minutes before breakfast or as advised by a physician.

 

  1. Mechanism of Action

Rabeprazole is a proton pump inhibitor (PPI) that works by irreversibly inhibiting the H+/K+ ATPase enzyme system of the gastric parietal cells. This inhibition leads to a significant reduction in gastric acid secretion, offering relief from acid-related issues like GERD and ulcers.

Domperidone is a dopamine D2 receptor antagonist that enhances gastric motility. It increases the movement of food through the stomach and intestines and prevents nausea and vomiting. It also helps in reducing bloating and discomfort associated with delayed gastric emptying.

  1. Indications and Uses

Rabeprazole DSR is indicated for:

  • Gastroesophageal Reflux Disease (GERD)
  • Acid reflux
  • Peptic ulcers
  • Zollinger-Ellison syndrome
  • Dyspepsia
  • Heartburn
  • Nausea and vomiting associated with acidity
  • Functional dyspepsia with delayed gastric emptying
  1. Dosage and Administration
  • Adult Dose: One capsule per day, 30 minutes before food.
  • Maximum Dose: Should not exceed two capsules daily unless prescribed.
  • Duration: Short-term treatment ranges from 4 to 8 weeks, depending on the condition.

Note: Always follow your doctor’s guidance for dosage and duration.

  1. Storage Conditions

To ensure the effectiveness of Rabeprazole DSR capsules:

  • Store at a temperature below 25°C.
  • Keep away from moisture and direct sunlight.
  • Store in the original blister pack until use.
  • Keep out of reach of children.

Proper storage maintains drug potency and safety.

  1. Popular Rabeprazole DSR Brands in India with MRP

Here are some commonly available Rabeprazole + Domperidone SR capsule brands in India along with their approximate MRPs (as of 2025):

Brand Name Manufacturer MRP (per strip of 10 capsules)
Rabekind DSR Mankind Pharma ₹105.00
Razo DSR Dr. Reddy’s Laboratories ₹130.00
Rebozen DSR Cipla Ltd ₹115.00
Rabicip DSR Sun Pharma ₹125.00
Rabium DSR Torrent Pharmaceuticals ₹120.00
Rabonik DSR Lupin Ltd ₹128.00
Rebetz DSR Zydus Cadila ₹110.00
Aciloc RD Cadila Healthcare ₹118.00
Rabifast DSR Alkem Laboratories ₹108.00
Rabekool DSR Intas Pharmaceuticals ₹112.00

Disclaimer: Prices may vary slightly based on pharmacy and location.

  1.  Side Effects

While it is generally well-tolerated, some patients may experience side effects such as:

Common Side Effects:

  • Headache
  • Diarrhea
  • Abdominal pain
  • Constipation
  • Dizziness
  • Dry mouth

Rare but Serious Side Effects:

  • Muscle cramps
  • Irregular heartbeat
  • Severe allergic reactions (rash, itching, swelling)
  • Liver function changes
  • Vitamin B12 deficiency (long-term use)
  • Low magnesium levels

Seek medical attention if severe symptoms occur.

  1. Precautions and Warnings

Before taking Rabeprazole DSR, consider the following:

  • Pregnancy and Breastfeeding: Use with caution. Consult a physician.
  • Liver/Kidney Conditions: Dose adjustment may be required.
  • Geriatric Use: Monitor for prolonged QT interval with Domperidone.
  • Alcohol: May worsen gastric symptoms.
  • Long-term Use Risks: B12 deficiency, osteoporosis, and Clostridium difficile infection.

Avoid self-medication and prolonged use without a doctor’s advice.

  1. Drug Interactions

Rabeprazole DSR may interact with:

  • Antifungals (e.g., Ketoconazole, Itraconazole)
  • Antibiotics (e.g., Clarithromycin)
  • Blood thinners (e.g., Warfarin)
  • Antiepileptic drugs (e.g., Phenytoin)
  • HIV medications
  • Antacids – Should be taken at a different time
  • Oral iron supplements – May affect absorption
Always inform your doctor about all current medications to avoid interactions.
  1. Frequently Asked Questions (FAQs)

Q1. Can I take Rabeprazole DSR on an empty stomach?

Yes. It is most effective when taken 30 minutes before meals, ideally before breakfast.

Q2. How long does Rabeprazole DSR take to show results?

Most patients experience relief within 1–3 days, but full benefits may take up to 7 days.

Q3. Is Rabeprazole DSR safe for long-term use?

It can be used for extended periods under medical supervision. However, long-term use may cause B12 deficiency, bone loss, or magnesium imbalance.

Q4. Can I stop taking Rabeprazole DSR suddenly?

No. Stopping abruptly may lead to acid rebound. Consult your doctor before discontinuation.

Q5. Can I take Rabeprazole DSR with antacids?

Yes, but they should be taken at least 1 hour apart to avoid reduced effectiveness.

Q6. Is this capsule available over the counter (OTC)?

In India, many pharmacies sell it without prescription, but it’s best to consult a healthcare provider before use.

Q7. Can Rabeprazole DSR be taken during pregnancy?

Only if prescribed. Domperidone crosses into breast milk and may not be safe without proper medical guidance.

  1. Conclusion

Rabeprazole DSR capsules provide dual action relief for acid-related gastrointestinal issues, making them a popular choice among doctors and patients in India. With the combination of Rabeprazole’s acid-suppressing capabilities and Domperidone’s prokinetic effects, this formulation offers fast and effective relief from conditions like GERD, acidity, and peptic ulcers.

However, self-medication is discouraged due to possible side effects and drug interactions. Always use Rabeprazole DSR under medical supervision and follow the prescribed dosage and duration.

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